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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM12
All Species:
10.61
Human Site:
S178
Identified Species:
23.33
UniProt:
O43184
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43184
NP_003465.3
909
99542
S178
K
L
K
S
V
R
G
S
C
G
S
H
H
N
T
Chimpanzee
Pan troglodytes
XP_508106
914
100282
S183
K
L
K
S
V
R
G
S
C
G
S
R
H
N
T
Rhesus Macaque
Macaca mulatta
XP_001087980
909
99411
S178
N
L
K
S
I
W
G
S
C
G
S
H
H
N
T
Dog
Lupus familis
XP_546274
909
99674
N183
D
R
V
L
P
S
M
N
Q
T
K
K
R
P
R
Cat
Felis silvestris
Mouse
Mus musculus
Q61824
903
98582
L176
S
M
T
N
I
Q
G
L
C
G
S
Q
H
N
K
Rat
Rattus norvegicus
Q9QYV0
816
88034
G177
I
Q
D
L
L
L
P
G
H
T
C
A
P
S
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507222
856
93750
L168
F
Q
K
N
Q
R
S
L
E
A
T
T
Y
K
L
Chicken
Gallus gallus
NP_001136322
922
101009
S193
N
L
E
I
I
P
G
S
C
G
H
Q
L
D
I
Frog
Xenopus laevis
O42596
935
104143
E196
V
Y
K
S
K
V
L
E
F
P
L
D
E
L
P
Zebra Danio
Brachydanio rerio
XP_001921148
773
83366
A163
Q
G
T
T
I
G
M
A
P
I
M
S
M
C
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999635
1023
111059
W182
D
R
R
D
K
K
T
W
V
F
D
V
D
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.3
94.8
43.7
N.A.
80.3
35.5
N.A.
43.3
71.5
28.3
56.7
N.A.
N.A.
N.A.
N.A.
35.8
Protein Similarity:
100
95.9
97.1
59.4
N.A.
88.1
50.3
N.A.
58
82.4
44.4
65.2
N.A.
N.A.
N.A.
N.A.
51.2
P-Site Identity:
100
93.3
80
0
N.A.
40
0
N.A.
13.3
33.3
13.3
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
93.3
86.6
6.6
N.A.
66.6
13.3
N.A.
33.3
53.3
13.3
33.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
10
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
46
0
10
0
0
10
0
% C
% Asp:
19
0
10
10
0
0
0
0
0
0
10
10
10
10
0
% D
% Glu:
0
0
10
0
0
0
0
10
10
0
0
0
10
0
0
% E
% Phe:
10
0
0
0
0
0
0
0
10
10
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
10
46
10
0
46
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
10
0
10
19
37
0
0
% H
% Ile:
10
0
0
10
37
0
0
0
0
10
0
0
0
0
10
% I
% Lys:
19
0
46
0
19
10
0
0
0
0
10
10
0
10
10
% K
% Leu:
0
37
0
19
10
10
10
19
0
0
10
0
10
10
10
% L
% Met:
0
10
0
0
0
0
19
0
0
0
10
0
10
0
0
% M
% Asn:
19
0
0
19
0
0
0
10
0
0
0
0
0
37
0
% N
% Pro:
0
0
0
0
10
10
10
0
10
10
0
0
10
10
10
% P
% Gln:
10
19
0
0
10
10
0
0
10
0
0
19
0
0
0
% Q
% Arg:
0
19
10
0
0
28
0
0
0
0
0
10
10
0
10
% R
% Ser:
10
0
0
37
0
10
10
37
0
0
37
10
0
19
10
% S
% Thr:
0
0
19
10
0
0
10
0
0
19
10
10
0
0
37
% T
% Val:
10
0
10
0
19
10
0
0
10
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
10
0
10
0
0
0
0
0
0
10
% W
% Tyr:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _